Guohua Ding

Personal Information

Name Guohua Ding
School or College School of Medicine
GenderMale
Position TitleProfessor
Phone027-88041919
Website
Emailghxding@gmail.com
Office AddressRenmin Hospital, Wuhan University

Research Interest

1. Glomerular podocyte biology and the molecular mechanism of glomerular sclerosis

2. Innate immunity in renal tubular interstitial injury


Education

1. 1971-1974 Wuhan University, School of Medicine, clinical medicine

2.1984-1990 Albert Einstein College of Medicine, Department of Pathology, Graduate, Ph.D.

3.1991-1993 Pennsylvania State University College of Medicine, kidney disease – hypertension, Postdoctoral


Oversea Study and Visit

1. 1984-1990 Albert Einstein College of Medicine of New York, Department of Pathology Graduate, Ph.D.

2. 1991-1993 Pennsylvania State University College of Medicine, kidney disease - hypertension, Postdoctoral


Honours and Awards

1. 2002  2nd prize of Hubei Province Natural Science Award

2. 2004  3rd prize of Hubei Science and Technology Progress Award

3. 2006  2nd prize of Hubei Science and Technology Progress Award

4. 2011  1st prize of Hubei Science and Technology Progress Award

5. 2006   Honor of "2005 outstanding contribution specialists in Hubei"

6. 2012   Honor of "Luojia Distinguished Scholar of Wuhan University"


Publications

1.  Pan Y, Wan J, Liu Y, Yang Q, Liang W, Singhal PC, Saleem MA, Ding G. PLA2 IB induces sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor.Sci Rep. 2014 Oct 22;4:6660. doi: 0.1038/srep06660.

2.  Liu L, Ding G. Rab25 expression predicts poor prognosis in clear cell renal cell carcinoma. Exp Ther Med, 2014,8(4):1055-1058.

3.  Liu L, Ding G. Effects of Different Blood Purification Methods on Serum Cytokine Levels and Prognosis in Patients With Acute Severe Organophosphorus Pesticide Poisoning.Ther Apher Dial. 2014 Nov 3. doi: 0.1111/1744-9987.12233.

4.  Wang H, Jia H, Lv X, Ding G. Peritoneal Catheter Fixation to the Abdominal Wall in Surgical Catheter Implantation to Prevent Malfunction.Blood Purif. 2014,38(2):109-114.

5.   Zha D, Chen C, Liang W, Chen X, Ma T, Yang H, Goor H, Ding G. Nephrin phosphorylation regulates podocyte adhesion through the PINCH-1-ILK-alpha-parvin complex. BMB Rep,2013,46(4):230-235.

6.  Liu Y, Liang W, Yang Q, Ren Z, Chen X, Zha D, Singhal P C, Ding G. IQGAP1 Mediates Angiotensin II-Induced Apoptosis of Podocytes via the ERK1/2 MAPK Signaling Pathway. Am J Nephrol,2013,38(5):430-444.

7.  Ma T, Zhu J, Chen X, Zha D, Singhal P C, Ding G. High glucose induces autophagy in podocytes. Exp Cell Res,2013,319(6):779-789.

8.  Chen X, Ren Z, Liang W, Zha D, Liu Y, Chen C, Singhal P C, Ding G. c-Abl mediates angiotensin II-induced apoptosis in podocytes. J Mol Histol,2013,44(5):597-608.

9.  Ma T, Ding G. Effects of residual renal function on left ventricle and analysis of related factors in patients with hemodialysis. Ren Fail,2013,35(2):198-203.

10.  Liu J, Hu F, Wang G, Zhou Q, Ding G. Lipopolysaccharide-induced expression of surfactant proteins A1 and A2 in human renal tubular epithelial cells.J Inflamm (Lond). 2013,10(1):2.

11. Hu F, Liang W, Ren Z, Wang G, Ding G. Surfactant protein D inhibits lipopolysaccharide-induced monocyte chemoattractant protein-1 expression in human renal tubular epithelial cells: implication for tubulointerstitial fibrosis. Clin Exp Immunol,2012,167(3):514-522.

12.  Yuan H, Ren Z L, Hu F Q, Liang W, Ding G H. Renin Induces Apoptosis in Podocytes Through a Receptor-Mediated, Angiotensin II-Independent Mechanism. Am J Med Sci, 2012 ,344(6):441-6.

13.  Ren Z, Liang W, Chen C, Yang H, Singhal P C, Ding G. Angiotensin II induces nephrin dephosphorylation and podocyte injury: role of caveolin-1. Cell Signal, 2012, 24(2): 443-450.

14.  Liang W, Chen C, Shi J, Ren Z, Hu F, van Goor H, Singhal P C, Ding G. Disparate effects of eplerenone, amlodipine and telmisartan on podocyte injury in aldosterone-infused rats. Nephrol Dial Transplant, 2011, 26(3): 789-799.

15.  Wang R, Ding G, Liang W, Chen C, Yang H. Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52E. Lipids Health Dis, 2010, 9: 120.

16.  Liu J, Hu F, Liang W, Wang G, Singhal P C, Ding G. Polymorphisms in the surfactant protein a gene are associated with the susceptibility to recurrent urinary tract infection in chinese women. Tohoku J Exp Med, 2010, 221(1): 35-42.

17.  Shui H, Gao P, Si X, Ding G. Mycophenolic acid inhibits albumin-induced MCP-1 expression in renal tubular epithelial cells through the p38 MAPK pathway. Mol Biol Rep, 2010, 37(4): 1749-1754.

18.  Chen C, Liang W, Jia J, van Goor H, Singhal P C, Ding G. Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways. Nephron Exp Nephrol, 2009, 113(1): e26-e34.

19.  Lv J, Jia R, Yang D, Zhu J, Ding G. Candesartan attenuates Angiotensin II-induced mesangial cell apoptosis via TLR4/MyD88 pathway. Biochem Biophys Res Commun, 2009, 380(1): 81-86.

20.  Yuling H, Ruijing X, Xiang J, Yanping J, Lang C, Li L, Dingping Y, Xinti T, Jingyi L, Zhiqing T, Yongyi B, Bing X, Xinxing W, Youxin J, Fox D A, Lundy S K, Guohua D, Jinquan T. CD19+CD5+ B cells in primary IgA nephropathy. J Am Soc Nephrol, 2008, 19(11): 2130-2139.

21.  Jia J, Ding G, Zhu J, Chen C, Liang W, Franki N, Singhal P C. Angiotensin II infusion induces nephrin expression changes and podocyte apoptosis. Am J Nephrol, 2008, 28(3): 500-507.

22.  Tian S, Ding G, Jia R, Chu G. Tubulointerstitial macrophage accumulation is regulated by sequentially expressed osteopontin and macrophage colony-stimulating factor: implication for the role of atorvastatin. Mediators Inflamm, 2006, 2006(2): 12919.

23.  Xia YM1, Ding GHXu SZJiang SYang HXXiong LY. Induction of lupus-like renal damages by double stranded DNA derived from Trypanosoma equiperdum. Chin Med J (Engl),2006,119(20):1753-6.

24.  Ding G, Reddy K, Kapasi AA, Franki N, Gibbons N, Kasinath BS, Singhal PC. Angiotensin II induces apoptosis in rat glomerular epithelial cells.Am J Physiol Renal Physiol. 2002 Jul;283(1):F173-80.

25. Ding G, Franki N, Kapasi AA, Reddy K, Gibbons N, Singhal PC. Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats.Exp Mol Pathol. 2001 Feb;70(1):43-53.

26. Ding G, van Goor H, Ricardo SD, Orlowski JM, Diamond JR. Oxidized LDL stimulates the expression of TGF-beta and fibronectin in human glomerular epithelial cells.Kidney Int. 1997 Jan;51(1):147-54.