Fan Mingwen

Personal Information

Name Fan Mingwen
School or College School of Stomatology
Position TitleProfessor
Office Address

Research Interest

·cariology and Endodontics, Oral biology


1951~1954  First junior high school of shashi, Hubei, China

    1954~1957  Third high school of Shashi, China

    1957~1960  Hubei Medical Univeristiy, China

  1960-1962    Faculty of Stomatology, Sichuan Medical University, China    DDS

Oversea Study and Visit

1981-1982      University of Montreal,Canada        Visiting Scholar

1982-1983      University of Toronto,Canada          Visiting Scholar

1990-1991      University of Louis Pasteur, France     Visiting Scholar

Honours and Awards

National Experts with Outstanding Contributions (1994)

Outstanding Dean of National Hospitals (1995)

Member of The 9th Chinese People's Political Consultative Conference (1998)

Contribution Award from The National Committee for Oral Health 2001

National Famous Teachers in Universities and collages (2006)

Outstaning Doctor prize from 3rd General Congress of Chinese Medical Doctor Association 2006


Honorary doctor of Chung Shan Medical University, Taiwan, China. (2013)



1.      2nd National Progress Prize in Science and Technology in 2009Fundamental and clinical research on Cariology and Endodontology

2.      2nd National Teaching Achievement Prize in 2009Establishing a comprehensive training system for stomatological talents of high quality

3.      Nomination for the 1st Progress Prize in Science and Technology from Ministry of Education in 2006Fundamental and clinical research on Cariology and Endodontology

4.      2rd Chinese Medical Science and Technology Prize in 2004 (The fundalmental research of DNA plasmid vaccine against dental caries)

5.      1st Progress Prize in Science and Technology of Hubei Province in 2001 (A series research on immunization of anti-caries)

2rd Progress Prize in Science and Technology of Ministry of Public Health in 1998Oral Biology


·1. Original Articles (In English, list top 20 ):

1)       Fan Ming-Wen*, et al. Christiane Mascres. Avenir du vaccin dans la prevention de la caries dentaire. L ‘Union Medicale, 1981; 110(11):13-18

2)       Fan MW*, Bian Z, Peng ZX, Zhong Y, Chen Z, Peng B, Jia R. A DNA vaccine encoding a cell-surface protein antigen of Streptococcus mutans protects gnotobiotic rats from caries. J Dent Res, 2002; 81(11):784-787.

3)       Guo JH, Jia R, Fan MW*, Bian Z, Chen Z, Peng B. Construction and immunogenic characterization of a fusion anti-caries DNA vaccine against PAc and glucosyltransferase I of Streptococcus mutans. J Dent Res, 2004; 83 (3):266-270.

4)       Rong Jia, Ji Hua Guo, Ming Wen Fan*, Zhuan Bian, Zhi Chen, Bing Fan, Fei Yu, Qing An Xu. Immunogenicity of CTLA4 fusion anti-caries DNA vaccine in rabbits and monkeys. Vaccine, 2006; 24:5192-5200

5)       Q.A. Xu, F. Yu, M.W. Fan*, Z. Bian, Z. Chen, B. Fan, R. Jia, and J.H. Guo. Immunogenicity and persistence of a targeted anti-caries DNA vaccine. J Dent Res, 2006; 85(10):915-918

6)       Niu YM, Sun JH, Fan MW*, Xu QA, Guo JH, Jia R, Li YH. A new fusion anti-caries DNA vaccine encoding antigens of both Streptococcus mutans and Streptococcus sobrinus. J Dent Res, 2009, 88(5):455-460

7)       Yuhong Li, Jie Jin, Yaping Yang, Zhuan Bian, Zhi Chen, Mingwen Fan*. Enhanced immunogenicity of an anti-caries vaccine encoding a cell-surface protein antigen of Streptococcus mutans by intranasal DNA prime-protein boost immunization. J Gene Med, 2009; 11: 1039–1047.

8)       Xu Qing-an, Yu Fei, Liu Chang, Liu Gao-xia, Fan Ming-wen*. Analysis of the molecular mechanisms of targeted anti-caries DNA plasmid enhancing antibody responses by gene arrays. The Journal of Gene Medicine, 2009, 11: 354–360

9)       Quan Xing, Qingsong Ye, Mingwen Fan*, Yi Zhou, Qiang Xu, Andrew Sandham. Porphyromonas gingivalis lipopolysaccharide inhibits the osteoblastic differentiation of preosteoblasts by activating Notch1 signaling. Journal of Cellular Physiology (J. Cell. Physiol.), 2010; 225: 106–114

10)    Yu Hong Li, ShengFu Huang, MinQuan Du, Zhuan Bian, Zhi Chen, Ming Wen Fan*. Immunogenic characterization and protection against Streptococcus mutans infection induced by intranasal DNA prime–protein boost immunization. Vaccine, 2010; 28:5370-5376

11)    Qingan Xu, Jenny Katz, Ping Zhang, Amit R. Ashtekar, Dalia E. Gaddis, Mingwen Fan* and Suzanne M. Michalek*. Contribution of a Streptococcus mutans Antigen Expressed by a Salmonella Vector Vaccine in Dendritic Cell Activation. Infection and Immunity, 2011; 79: 3792–3800

12)    Xi Chen, Minquan Du, Mingwen Fan*, Jan Mulder, Marie-Charlotte Huysmans, Jo E. Frencken. Effectiveness of two new types of sealants: retention after 2 years. Clin Oral Invest, 2012;16:1443–1450

13)    Li Xiaoyan, Yang Guobin, Fan Mingwen*. Effects of Homeobox Gene Distal-less 3 on Proliferation and Odontoblastic Differentiation of Human Dental Pulp Cells. J Endod. 2012;38(11):1504-1510.(IF=2.880)

14)    Liulin Chen, Junming Zhu, Yuhong Li, Jie Lu, Li Gao, Huibi Xu, Mingwen Fan*, Xiangliang Yang. Enhanced Nasal Mucosal Delivery and Immunogenicity of Anti-Caries DNA Vaccine through Incorporation of Anionic Liposomes in Chitosan/DNA Complexes. PLOS ONE, 2013;8(8):e71953-e71953

15)    Xuan Hu, Xi Chen, Mingwen Fan*, Jan Mulder and Jo E. Frencken. What happens to cavitated primary teeth over time? A 3.5-year prospective cohort study in China. International Dental Journal, 2013; 63(4): 183-188

16)    S. Zhang, X. Yang & M. Fan*. BioAggregate and iRoot BP Plus optimize the proliferation and mineralization ability of human dental pulp cells. International Endodontic Journal, 2013;46, 923–929

17)    Rong Jia, Xiaoxing Li, Cheng Yu, Mingwen Fan*, Jihua Guo. The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells. Immunology Letters, 2013; 153(1–2):27-32

18)    Ling-kai SU, Fei YU, Zhao-fei LI, Chang ZENG, Qing-an XU, Ming-wen FAN*. Intranasal co-delivery of IL-6 gene enhances the immunogenicity of anti-caries DNA vaccine. Acta Pharmacologica Sinica, (2014) 35: 592–598

19)    Xuan Hu, Xi Chen, Lu Ye, Ming-Wen Fan, Marie-Charlotte Huysmans4 and Jo E Frencken. Comparison between visual clinical xamination and the replica method for assessments of sealant retention over a 2-year period. International Journal of Oral Science, 2014, 6:111–115

20)    Lili Gan, Rong Jia, Lili Zhou, Jihua Guo*, Mingwen Fan*. Fusion of CTLA-4 with HPV16 E7 and E6 nhanced the Potency of Therapeutic HPV DNA Vaccine. PLOS ONE 201499):e108892



2. Books and Monographs(In English, list top 10 ):

w Modern Oral Medicine                        Science and Technology Press   01-2003

w Introduction of Clinical Oral Medicin      Higher Education Press  09-2003

w Cariology2rd Edition                   People's Medical Publishing House  10-2003

w Oral Biology2rd Edition           People's Medical Publishing House  07-2004

w Cariology and Endodontology               Hubei Science and Technology Press  10-2004

w New Progress of Oral Medicine 2005        People's Medical Publishing House  04-2005

w Chinese Version of  Dental Caries       People's Medical Publishing House  03-2006

w Cariology and Endodontology3rd Edition) People's Medical Publishing House 01-2008

w Cariology and Endodontology4th Edition) People's Medical Publishing House 07-2012

w “A Collection of Classic Cases of Composite Restoration” People'smilitary Medical press 2009.6 

w “Aesthetic multilayer restoration of composite resin—foundation and clinical treatment”  People's Medical Publishing House  2011.10