Zhang Zhao-hui

Personal Information

Name Zhang Zhao-hui
School or College School of Medicine
Position TitleProfessor , Chief physician
Office AddressNo.238 Jiefang Road, Wuchang District ,Wuhan city,Hubei province

Research Interest

Research direction:Cerebrovascular disease and relevent disease.

The most important achivements :Study systematically the mechanism of cerebral ischemia injury and neural protection of traditional chinese medicine,define apoptosis feature of brain ischemia-reperfusion injury mechanism further surrounding oxidative stress,reveal the molecular structure included in ligustrazine and sodium ferulate scavenging various reactive oxygen free radical direcetly and their neural protection machanism,discover and research mechanism of influence of Lysophosphatidic acid on neurovascular unit and its clinical significance. 


·Graduate from Hubei Medical College for bachelor’s degree in June in 1985

·Graduate from Hubei Medical University for master’s degree in June in 1992

·Graduate from Wuhan University for Doctor’s degree in June in 2002

Oversea Study and Visit

·Study futher at BOSCO hospital in Turin of Italy during 1999 and 2002

Honours and Awards

·Win the second prize(the first person) in excellent thesis of national ministry of health in 1992

·Win the third prize in Hubei Health Department technological award as the chief person doing in 1997

·Win the second prize(the first person) in Hubei Health Department technological award in 1997

·Win the first BOSHISHENG WANDAI scholar of Wuhan University in 2001

·Win excellent Doctor thesis scholarship of Wuhan University in 2002

·Win the second prize(the first person) in Hubei technological award in 2002


1.Proliferating cell nuclear antigen binds DNA polymerase-β and mediates 1-methyl-4-phenylpyridinium-induced neuronal death. PLoS One. 2014, 9(9):e106669.

2.Role of Rho kinase in lysophosphatidic acid-induced altering of blood-brain barrier permeability. Int J Mol Med, 2014,33(3):661-669,.

3.Phospho-Rb mediating cell cycle reentry induces early apoptosis following oxygen-glucose deprivation in rat cortical neurons. Neurochem Res. 2012, 37(3): 503-11.

4.Tanshinone IIA protects PC12 cells from beta-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Molecular biology reports, 2012, 39(6): 6495-6503.

5.The role of oxidative stress in neuromelanin synthesis in PC12 cells. Neuroscience,