Zhengguo Cao

Personal Information

Name Zhengguo Cao
School or College School of Stomatology
Position TitleProfessor
Office Address237 LuoYu Road, Wuhan, 430079

Research Interest

·1. Pathogenic mechanism and Host factor in Periodontology by Animal model Study of experimental Periodontitis in vivo and in vitro

·2. Development biology of Bone and Tooth by Transgenic animal generation in vivo and in vitro



School of Stomatology, Wuhan University, CHINA     DDS     Dentistry


School of Stomatology, Wuhan University, CHINA     M.S      Periodontology


School of Stomatology, Wuhan University, CHINA     Ph.D     Periodontology


Baylor College of Dentistry, Texas A&M University, USA Postdoc  Development Biology

Oversea Study and Visit

2008.4-2010.10: Baylor College of Dentistry, Texas A&M University, USA Postdoc  

2013.10-25-30: Clinical dental office of Dr Kwan, San Francisco, USA, Microsurgery training

2014-9-20: 4th ESMD, workshop on microsurgery of periodontology, DR. Carlo Ghezzi·

Honours and Awards

2013-          Chutian young scholar of Hubei Province

2014--         Luojia distinguished professor Wuhan university


1.      Yinshi Ren, Xianglong HanStephen E. Harris, Zhengguo CaoJian Q. Feng. Removal of the Sost Gene or Blocking Its Function By Sclerostin-antibody Rescues Periodontia Defects in the Periostin Knock-out Mouse. J Bio chem. 2014, in press

2.      Shu-xian Lin, Qi Zhang, Zheng-guo Cao, Yong-bo Lu, Hua Zhang, Bao-zi Yuan, Kevin YanYing Liu, Chunlin Qin, Zhi Chen, and Jian Q. Feng. DMP1 Functions as an Extracellular Matrix Protein in vivo. J Bio chem. 2014, 28931):21533-43

3.      ZhengguoCao*#, RubingLiu#, Hua Zhang, HaiqingLiaoYufengZhang, Jian Q Feng.Osterix Controls Cementoblast Differentiationsthrough Downregulation of Wnt-signaling via  Enhancing DKK1 Expressions. International Journal of Biological Sciences, 2014, in press ,IF:4.37

4.      Rubing Liu, zhengguo Cao*. osterix combined with GAM: A potential integrated strategy for achieving cementum regeneration. Dental Hypotheses, 2014, in press

5.      Liu L, Li C, Xiang J, Dong W, Cao Z *. Over-expression and potential role of cyclophilin A in human periodontitis. Over-expression and Potential role of Cyclophilin A (CypA) in Human Periodontitis. J Periodont Res 2013; 48(5):615–622(Corresponding author, Impact Factor:2.13)

6.      Cao Z, Zhang H, Zhou X, Han X, Ren Y, Gao T, Xiao Y, de Crombrugghe B, Somerman MJ, Feng JQ. Genetic evidence for the vital function of Osterix in cementogenesis. Journal of Bone and Mineral Research 201227(5):1080-92.  Impact factor: 7.056)

7.      Afsaneh Rangiani *, Zhengguo Cao* , Yao Sun1, Yongbo Lu , Tian Gao , Baozhi Yuan , Anika Rodgers ,Chunlin Qin , Makoto Kuro-o  Jian Q. Feng Protective Roles of DMP1 in High Phosphate Homeostasis. Plos One2012,7(8)e42329( Impact factor: 4.1)

8.      Rangiani A, Cao ZG, Liu Y, Voisey Rodgers A, Jiang Y, Qin CL, Feng JQ. Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation. Int J Oral Sci. 2012 Dec;4(4):189-95, IF:2.719

9.         B. Jiang *, Z. Cao *, Y. LU , BC. Janik , S. Lauziere , Y. Xie , A. Poliard , C. Qin  LM. Ward4#, and JQ. Feng.   DMP1 C-terminal Mutant Mice Recapture the Human ARHR Tooth Phenotype. Journal of Bone and  Mineral Research, 20102510):2155-2164 (co-first author ,  Impact factor: 7.056)

10.     Zhengguo Cao , Baichun Jiang , Yixia Xie , Chuan-ju Liu and Jian Q. Feng. GEP, a Local Growth Factor, is Critical for Odontogenesis and Amelogenesis. International Journal of Biological Sciences, 2010; 6(7):719-729 , Impact factor: 3.215)

11.     Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ. The biological function of DMP1 in osteocyte maturation is mediated by its 57 kDa C-terminal fragment. Journal of Bone and  Mineral Research. 2011 26(2):331-40.

12.     Zhengguo Cao, Chengzhang Li , Guangxun Zhu.Inhibitory effects of baicalin on IL-1β- induced MMP-1/TIMP-1 and its stimulated effect on Collagen-I synthesis in human periodontal ligament cells . European Journal of Pharmacology, 20106411-6, Impact Factor:2.737)

13.     Lihua Liu, Chengzhang Li, xia Cai, Junbo Xiang, Zhengguo Cao*. Cyclophilin A (CypA) is associated with the inflammatory infiltrates and alveolar bone destruction of an experimental periodontitis. Biochemical and Biophysical Research Communications, 2010,391:1000-1006(Corresponding author, Impact Factor:2.597)

14.     Zhengguo Cao, Chengzhang Li,Junbo Xiang. Effect of MMP-1 promoter genotype on the IL-1β induced MMP-1 production in human periodontal ligament cells. J Periodontal Res2010,45,109-115  (Impact Factor:2.128)

15.     Jianbo Liu, Zhengguo Cao*Chengzhang Li. Intermittent PTH administration: A novel therapy method for periodontitis-associated alveolar bone loss. Medical Hypotheses2009, 72, 294-296 (co-first author, Impact Factor:1.416)

16.     Junbo Xiang, Zhengguo Cao*Chengzhang Li. Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in Healthy and Inflamed Human Gingiva. Quintessence International ,2009,40(8):683-690. (co-first author, Impact Factor:0.811)  

17.     Zhengguo Cao, Junbo Xiang, ChengZhang Li. Expression of Extracellular Matrix Metalloproteinase Inducer and Enhancement of the Production of Matrix Metalloproteinase-1 in Tongue Squamous Cell Carcinoma. International Journal of Oral & Maxillofacial Surgery, 2009,38: 880-885 (Impact Factor:1.487)

18.     Zhengguo Cao, Junbo XiangChengzhang Li. A potential role of EMMPRIN by regulating ECM degradation in peridontitis. Medical Hypotheses2007695, 1102–1104 (Impact Factor:1.3)

19.     Zhengguo Cao, ChengZhang LiGuangxun Zhu. MMP-1 promoter gene polymorphism and Susceptibility to Chronic Periodontitis in a Chinese population. Tissue Antigens 2006, 68 (1): 38-43. (Impact Factor: 2.747)

20.     Zhengguo Cao, ChengZhang Li. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhance oral squamous cell carcinoma susceptibility in Chinese population. Oral Oncology, 2006, 421:32-38. (SCI, Impact Factor: 2.266)

21.     Zhengguo Cao, Chengzhang Li, Lijian Jin and Esmonde F Corbet Association of MMP-1 promoter polymorphism with generalized aggressive periodontitis in a Chinese population. J Periodontal Res2005406):427-431. (SCI,Impact Factor:1.947)


22.     Lihua Liu, Chengzhang Li, Xia Cai, Junbo Xiang, Zhengguo Cao, Weili Dong. The temporal expression and distribution of extracellular matrix metalloproteinase (EMMPRIN) during the development of periodontitis in an animal model. J Periodont Res 2010;45:541-549

23.     Junbo XiangChengzhang Li, Weili Dong, Zhengguo Cao. Expression of matrix metalloproteinase -1, -2 and extracellular metalloproteinase inducer (EMMPRIN) stimulated with interleukin-1 beta in human periodontal ligament cells. J Periodontal Res, 200944(6): 784-3

24.     Weili Dong, Junbo XiangChengzhang Li, Zhengguo Cao. Increased Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is Associated with Matrix Metalloproteinase -1, 2 in Gingival Tissues from Periodontitis-affected Patients. J Periodontal Res, 2009,44(1):125-132

25.     Zhu Guang-xun, Li Cheng-zhang, Cao Zheng-guo, Esmonde F Corbet and Lijian Jin. Analysis of the Toll-like receptor (TLR) 2 and 4 gene polymorphisms in a Chinese population with periodontitis. Quintessence International , 2008393):217226(SCI,Impact Factor:0.54)

26.     Zhu Guang-xun, Li Cheng-zhang, Cao Zheng-guo. Inhibitory Effect of Flavonoid Baicalin on Degranulation of Human Polymorphonuclear leukocytes induced by Interleukin-8. Journal of Ethnopharmacology, 2007,109: 325-330(SCI,Impact Factor:1.554)

27.     Ge-fei Du, Cheng-zhang Li *, Han-zheng Chen, Xin-ming Chen, Zheng-guo Cao, Shu-huan Shang. Rose Bengal Staining in Detection of Oral Precancerous and Malignant Lesions with Colorimetric Evaluation: a Pilot Study . International Journal of Cancer, 2007,120:1958-1963  (SCI,Impact Factor:4. 7)

28.    Xia Cai, Cheng-zhang Li *,Ge-fei DuZhengguo Cao. Protective effects of baicalin on ligature-induced periodontitis in rats. J Periodontal Res, 2008431421, (SCI,Impact Factor:1.947)

29.    Huang S-F, Li Y-H, Ren Y-J, Cao Z-G, Long X. The effect of a single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter on force-induced MMP-1 expression in human periodontal ligament cells. Eur J Oral Sci 2008; 116: 319–323.


30.    Zhengguo Cao,  Chengzhang Li, Xianqun Wu. Effects of baicalin on human periodontal ligament cells. Chinese Journal of Dental Research, 2005, 8(1): 59-63

31.     曹正国。LBL-PBL双轨教学方法在牙周病教学中效果评估。医药前沿,2012,6:55-57

32.    郑细娇,严翔,曹正国*。中重度牙周炎松牙固定的临床研究。口腔医学研究,2013,2910):973-977

33.    郑细娇,曹正国*,严翔,程凯。美学牙冠延长术对于烤瓷修复前的准备。口腔医学研究,2014,303):249-251

34.    柴红波,廖海清,曹正国* 。上皮下结缔组织移植术对牙龈退缩治疗效果的Meta分析。口腔医学研究,2014,309):249-251

35.    孙素珍,曹正国*,戴杰,吴志芳。牙龈瘤切除术后的美学处理与分析。口腔医学研究,2015

36.    谭瑞雪, 曹正国*TNF-α-308位点多态性与慢性牙周炎相关性。口腔医学研究,2015

37.     马兰,沈士倩,王珍,张维伟综述 曹正国审校。亲环蛋白A与口腔恶性肿瘤间的关系. 《国际口腔医学杂志》 20096363

38.     李成章 曹正国 杨茹 尚姝环 金力坚 Cobert EF。黄芩苷对牙龈成纤维细胞和牙周膜细胞pro-MMP-1/MMP-3 表达的影响。中华口腔医学杂志2004393):197200

39.     曹正国 李成章 刘小平 吴献群。黄芩苷对人牙周膜细胞增殖和总蛋白含量的影响。口腔医学研究杂志,2003101;10-12

40.     李成章 曹正国 樊明文 刘小平。黄芩苷对人牙周韧带细胞超微结构的影响。牙体牙髓牙周病学杂志,200313(2):76-77

41.   曹正国综述 李成章审校。基质金属蛋白酶-1启动子基因的单核苷酸多态性及其与牙周炎的关系。国外医学口腔医学分册,2003306):420421

42.     曹正国综述 李成章审校。常用蛋白交联方法及其对胶原的影响。国外医学生物医学工程分册,2001244):187191

43.     曹正国综述 李成章审校。肝细胞生长因子与牙周病。国外医学口腔医学分册,2004312):113-114

44.     向军波 曹正国综述 李成章审校。细胞外基质金属蛋白酶诱导因子与牙周炎的关系。国外医学口腔医学分册,2005325):336-338

45.     张立乐 曹正国 李成章。2次和5次口腔卫生指导效果的评价。口腔医学研究杂志,2004,11(5): 549550

46.     罗志晓 李成章 曹正国。黄芩苷对牙龈成纤维细胞和牙周膜细胞上ICAM-1表达调节的研究。口腔医学研究杂志,2004,11(2):123-125

47.     罗志晓 李成章 曹正国IL-1β对牙龈成纤维细胞和牙周膜细胞上ICAM-1表达调节的免疫组化研究。郧阳医学院学报,20025281283

48.     潘杏兰 程祥荣 杨惠 曹正国。骨髓基质细胞在钙磷涂层纯钛表面早期黏附的实验研究。中国口腔种植学杂志,200272):5759